Silicon-Substituted Calcium Phosphate Biomaterials-The Effect of Strut Porosity on Osteoinduction
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754 ©2011 Society For Biomaterials
منابع مشابه
The effects of microporosity on osteoinduction of calcium phosphate bone graft substitute biomaterials.
The effect of increasing strut porosity on the osteoinductive ability of silicate substituted calcium phosphate (SiCaP) biomaterials was investigated in an ectopic ovine model. Implants with strut porosities of 22.5%, 32.0% and 46.0% were inserted into the parapsinalis muscle. At 8, 12 and 24 weeks histological sections were prepared. Sections were examined using backscattered scanning electron...
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In this work, we report high biological performance of silicon substituted nano hydroxyapatite (nHA) prepared by immersion of calcium phosphate and sodium silicate as precursors in Simulated Body Fluid (SBF) solution for 24, 36, 48 and 72 hrs at 37°C. Characterization and chemical analysis of the synthesized powders were performed by Fourier transform, infrared spectroscopy (FT-IR), X-ray powde...
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Although calcium phosphate-containing biomaterials are promising scaffolds for bone regenerative strategies, the osteoinductive capacity of such materials is poorly understood. In this study, we investigated whether endogenous mechanisms of in vivo calcium phosphate-driven, ectopic bone formation could be identified and used to induce enhanced differentiation in vitro of the same progenitor pop...
متن کاملSilicate-substituted calcium phosphate with enhanced strut porosity stimulates osteogenic differentiation of human mesenchymal stem cells.
While many synthetic ceramic bone graft substitutes (BGSs) have osteoconductive properties (e.g. provide a physical scaffold for osteointegration of surrounding bone tissue), certain BGSs are osteostimulative in that they actively upregulate mesenchymal stem cell proliferation and stimulate differentiation into osteoblast-like cells. The osteostimulative properties of silicate-substituted calci...
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تاریخ انتشار 2010